C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2561533
This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor Clq. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
L'invention concerne des anticorps anti-P-sélectine et, en particulier, des anticorps anti-P-sélectine et leurs variantes contenant une partie Fc d'origine humaine et ne se liant pas au facteur complémentaire C1q. Ces anticorps possèdent des propriétés nouvelles et avantageuses pour le patient atteint d'ischémie critique des membres ou d'occlusion artérielle périphérique (CLI/PAOD).
Graus Yvo
Himber Jacques
Jansen-Molenaar Miranda
Kling Dorothee
Kopetzki Erhard
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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