Anti- p2x7 peptides and epitopes

Details Anti- p2x7 peptides and epitopes Anti- p2x7 peptides and epitopes

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/05 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2729868

The invention relates to the identification of a novel epitope on non- functional P2X7 receptors which are implicated in cancer. The epitope includes a region from two adjacent monomers within the three subunit receptor. Antibodies which bind to the epitope and peptides for generating the antibodies are described. The antibodies and peptides are useful in the diagnosis and treatment of cancer.

L'invention concerne l'identification d'un nouvel épitope sur des récepteurs P2X7 non fonctionnels qui sont impliqués dans le cancer. L'épitope comprend une région de deux monomères adjacents dans le récepteur à trois sous-unités. L'invention concerne des anticorps qui se lient à l'épitope et des peptides pour produire les anticorps. Les anticorps et les peptides sont utiles dans le diagnostic et le traitement du cancer.

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