C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2365104
The present invention relates to nucleotide sequences which encode polypeptides of antibodies against the p53 protein in vertebrates, and to the polypeptides and antibodies (or fragments thereof) encoded by those nucleotide sequences. The invention also relates to nucleotide sequences and polypeptide sequences for use in the development of diagnostic and therapeutic compositions, and to methods of using those diagnostic and therapeutic compositions in the diagnosis and treatment of cancer, rheumatoid arthritis and other disease states which exhibit abnormalities of p53.
L'invention concerne des séquences nucléotidiques qui codent les polypeptides d'anticorps dirigés contre la protéine p53 chez les vertébrés, ainsi que des polypeptides et des anticorps (ou fragments de ceux-ci) codés par lesdites séquences nucléotidiques. Elle porte également sur des séquences nucléotidiques et des séquences polypeptidiques à utiliser dans la mise au point de compositions diagnostiques et thérapeutiques, et sur des méthodes d'utilisation desdites compositions diagnostiques et thérapeutiques dans le diagnostic et le traitement du cancer, de la polyarthrite rhumatoïde et d'autres états pathologiques dans lesquels on constate des anomalies au niveau de p53.
Coomber David William John
Ward Robyn Lynne
Gowling Lafleur Henderson Llp
St. Vincent's Hospital Sydney Limited
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