Anti-p53 single-chain antibody fragments and their uses

Details Anti-p53 single-chain antibody fragments and their uses Anti-p53 single-chain antibody fragments and their uses

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2268865

The invention concerns single-chain antibodies directed against the p53 protein, capable of being expressed in tumoral cells, capable of restoring a DNA binding in vitro and a transcription activator function in vivo. The invention also concerns nucleic acids coding for these molecules, the vectors containing them and their uses.

La présente invention concerne des anticorps à chaîne unique dirigés contre la protéine p53, capables d'être exprimés dans des cellules tumorales, capables de restaurer un fonction DNA binding in vitro et une fonction d'activateur transcriptionnel in vivo. Elle concerne également les acides nucléiques codant pour ces molécules, les vecteurs les contenant et leurs utilisations.

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