C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/139, 195/1.1
C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07K 16/10 (2006.01) C07K 16/42 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1341277
The present invention provides a method of manufacture of an anti-paratopic antibody comprising the steps of: (1) selecting from a pool of antibodies occurring in one species a prototypic set the members of which are effective in binding a specific antigen (or antigen epitope), and (2) utilizing one or more members of said prototypic set, or paratopic fragments thereof, as an immunogen in a host of a different species, or in an in vitro incubation system comprising cells derived from the same or a different species, to produce antibodies having a characteristic which is anti-paratopic with respect to said immunogen to produce a synthetic replicate of the specific antigen or epitope. Antigen (or antigen epitope), and monoclonal antibodies, vaccines and processes of immunisation employing the product of the method of manufacture are also described.
561678
Biosolutions Pty Ltd.
Mccarthy Tetrault Llp
Mcgready Roland Keith
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