C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 38/43 (2006.01) A61K 39/00 (2006.01) C07K 14/00 (2006.01) C07K 14/16 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12N 15/52 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2314267
The present invention provides an anti-pathogen system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated by a pathogen infection. The anti-pathogen system effectively kills or injures cells infected by one or a combination of different pathogens. Further provided are protein transduction domains that provide enhanced transduction efficiency.
L'invention concerne un système anti-pathogène contenant une ou plusieurs protéines hybrides, qui comprend un domaine de transduction et un domaine cytotoxique. Le domaine cytotoxique est spécifiquement activé par une infection pathogène. Le système anti-pathogène tue ou affaiblit effectivement les cellules infectées par un pathogène ou une combinaison de différents pathogènes. L'invention concerne en outre des domaines de transduction de protéine dont l'efficacité de transduction est améliorée.
Ridout & Maybee Llp
Washington University
LandOfFree
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