C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2460587
Methods of making and selecting engineered antibodies and/or antibody fragments provide maximized binding affinity for a predetermined target and minimized immunogenicity when such antibodies are administered to a target species. Libraries containing variants of the engineered antibodies are also provided. In particularly useful embodiments, anti-PGDF antibodies and compositions are produced which are useful in the treatment of various cancers.
L'invention concerne des procédés de production et de sélection d'anticorps et/ou de fragments d'anticorps mis au point, qui permettent d'obtenir une affinité de liaison maximisée pour une cible prédéterminée, et une immunogénicité réduite au minimum lorsque de tels anticorps sont administrés à une espèce cible. L'invention concerne également des banques contenant des variants desdits anticorps mis au point. Selon des modes de réalisation particulièrement utiles, des procédés permettent d'obtenir des compositions et des anticorps anti-PGDF qui sont utiles à des fins de traitement de divers cancers.
Bowdish Katherine S.
Frederickson Shana
Kretz-Rommel Anke
Alexion Pharmaceuticals Inc.
Mcfadden Fincham
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