C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/00 (2006.01) A61K 31/27 (2006.01) A61K 38/04 (2006.01) C07C 271/22 (2006.01) C07D 211/76 (2006.01) C07K 5/02 (2006.01) C07K 7/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2127187
Abstract The present invention provides a group of novel compounds that inhibit the proteolytic activity of 3C proteases which are found in picornaviruses, particularly rhinoviruses. In picornaviruses the RNA genome is translated into a single large viral polyprotein precursor. The precursor demonstrates auto-proteolytic activity, cleaving itself into mature viral gene products. Therefore, compounds of the current invention are particularly useful in treating picornaviral infections by interrupting the processing of the viral gene products into mature and infectious viral particles. The current invention also provides a novel process the preparation of compounds of the current invention. The process entails the selective reduction of an imide intermediate representing a marked improvement over processes known in the art for making peptidyl-aldehydes.
Hammond Marlys
Kaldor Stephen W.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Anti-picornaviral agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-picornaviral agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-picornaviral agents will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2086256