C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2606450
An antibody having the following properties or an active fragment thereof or a derivative of the antibody or the fragment: a) it is capable of binding specifically to human platelet membrane glycoprotein VI (GPVI); b) it has a low platelet-activating effect and/or a low effect of inducing the decrease in platelets in vivo; and c) it can obliterate GPVI on the platelet membrane at least partly when it is contacted with a platelet.
L~invention concerne un anticorps ou un fragment actif découlant de celui-ci, ou un dérivé de l'anticorps ou du fragment, ayant les propriétés suivantes : a) il est capable de se lier spécifiquement à la glycoprotéine VI de la membrane plaquettaire humaine (GPVI) ; b) il a un faible effet d~activation plaquettaire et/ou d'induction de la baisse plaquettaire in vivo ; et c) il peut, au moins en partie, oblitérer GPVI sur la membrane plaquettaire quand il est au contact d~une plaquette.
Furusako Shoji
Honda Motoyasu
Hosaka Yoshitaka
Hotta Yumi
Kawahara Tetsushi
Fetherstonhaugh & Co.
Mochida Pharmaceutical Co. Ltd.
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