Anti-proliferative composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/06 (2006.01) A61K 31/01 (2006.01) A61K 31/352 (2006.01) A61K 31/357 (2006.01) A61K 31/7048 (2006.01) A61K 36/48 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2468180

Non-estrogen-dependent hyperproliferation of cells in animals or humans can be prevented or treated by means of a pharmaceutical or nutritional composition containing a combination of at least three components from: a) two or more inhibitors of the G1/S phase of the cell cycle; and b) two or more inhibitors of the G2/M phase of the cell cycle; and c) two or more inhibitors of protein tyrosine kinase activity. Especially, component a) comprises two or more compounds selected from flavanolignans, carotenoids and isoflavone; component b) comprises two or more compounds selected from flavanolignans, hydroxylated stilbenes, isoflavones and apigenin; and component c) comprises two or more compounds selected from flavanolignans and isoflavones.

Il est possible d'empêcher ou de traiter une hyperprolifération cellulaire non dépendante d'oestrogènes chez l'homme ou l'animal au moyen d'une composition pharmaceutique ou nutritionnelle renfermant une combinaison d'au moins trois composants: a) au moins deux inhibiteurs de la phase G1/S du cycle cellulaire; b) au moins deux inhibiteurs de la phase G2/M du cycle cellulaire; et c) au moins deux inhibiteurs de l'activité de la protéine tyrosine kinase. Spécifiquement, le composant a) comprend au moins deux composés pris dans des flavanolignans, carotenoïdes et isoflavone; le composant b) comprend au moins deux composés pris dans des flavanolignans, stilbènes hydroxylés, isoflavones and apigénine; et le composant c) comprend au moins deux composés pris dans des flavanolignans et des isoflavones.

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