C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2586356
The present invention is related to antibodies directed to the antigen properdin and uses of such antibodies. In particular, n accordance with the present invention, there are provided fully human monoclonal antibodies directed tot he antigen properdin. Nucleotide sequences encoding, and polypeptides comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR~s), specifically from FR1 through FR4 or CDR1 through CDR3, are provide. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
La présente invention concerne des anticorps destinés à la properdine antigène et des utilisations de ces anticorps. Cette invention concerne en particulier des anticorps monoclonaux complètement humains destinés à la properdine antigène. Cette invention concerne aussi des séquences nucléotidiques et des polypeptides comprenant ces séquences codantes pour des molécules d'immunoglobuline de chaîne lourde et de chaîne légère, en particulier les séquences correspondant à des séquences de chaînes lourde et légère contiguës couvrant des régions de structure et/ou des régions de détermination de complémentarité (CDR~s) spécifiquement de FR1 à FR4 ou de CDR1 à CDR3. Cette invention concerne enfin des hybridomes ou d'autres lignées cellulaires exprimant ces molécules d'immunoglobuline et des anticorps monoclonaux.
Gazit-Bornstein Gadi
Keyt Bruce
Senaldi Giorgio
Yang Xiao-Dong
Zapata Gerardo
Amgen Fremont Inc.
Gazit-Bornstein Gadi
Keyt Bruce
Senaldi Giorgio
Smart & Biggar
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