C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/67 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2387108
The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
L'invention concerne des anticorps qui sont dirigés contre l'antigène de cellules souches de la prostate (PSCA) et s'intériorisent lors de leur liaison à cet antigène sur un mammifère, in vivo. L'invention concerne également des compositions comprenant un anticorps dirigé contre l'antigène PSCA, ainsi qu'un véhicule, ces compositions pouvant être fournies dans un article de fabrication, ou dans une trousse. Un autre aspect de l'invention concerne un acide nucléique isolé codant pour un anticorps anti-PSCA, un vecteur d'expression comprenant cet acide nucléique isolé, des cellules produisant les anticorps anti-PSCA, ainsi qu'un procédé de production de tels anticorps anti-PSCA. D'autres aspects de l'invention portent sur un procédé de destruction d'une cellule cancéreuse exprimant PSCA, ce procédé consistant à mettre en contact la cellule cancéreuse avec l'anticorps anti-PSCA, ainsi qu'un procédé servant à soulager ou traiter un mammifère atteint d'un cancer exprimant PSCA et consistant à administrer à ce mammifère une dose efficace sur le plan thérapeutique de l'anticorps anti-PSCA.
Devaux Brigitte
Keller Gilbert-Andre
Koeppen Hartmut
Lasky Laurence A.
Genentech Inc.
Smart & Biggar
LandOfFree
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