Anti-psgl-1 antibodies and methods of identification and use

Details Anti-psgl-1 antibodies and methods of identification and use Anti-psgl-1 antibodies and methods of identification and use

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2724415

The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for such antibodies and binding fragments thereof and to methods of therapeutic use thereof.

L'invention concerne des anticorps et des fragments de liaison de ces derniers, qui se lient avec une affinité et une spécificité élevées à la glycoprotéine ligand de la sélectine P humaine 1 (PSGL-1) et qui bloquent la liaison de la sélectine et de la chimiokine à la PSGL-1 exprimée sur les leucocytes, les lymphocytes et les cellules endothéliales, inhibant par conséquent la migration et/ou le roulement desdites cellules. L'invention porte aussi sur des procédés de criblage desdits anticorps et fragments de ces derniers et sur des procédés d'utilisation thérapeutique de ceux-ci.

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