Anti-rantes antibodies and methods of use thereof

Details Anti-rantes antibodies and methods of use thereof Anti-rantes antibodies and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2695237

The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.

L'invention porte sur des anticorps monoclonaux entièrement humains, et sur des fragments de ceux-ci, qui se lient à la chimiokine régulée lors de l'activation, exprimée par des lymphocytes T normaux et sécrétée (RANTES, CCL5), modulant ainsi l'interaction entre RANTES et un ou plusieurs de ses récepteurs, tels que, par exemple, CCR1, CCR3, CCR4 et CCR5, et/ou modulant les activités biologiques de RANTES. L'invention porte également sur l'utilisation de ces anticorps anti-RANTES ou n'importe quels anticorps anti-RANTES dans la prévention ou le traitement de troubles apparentés à l'immunité et dans l'amélioration d'un ou plusieurs symptômes associés à un trouble apparenté à l'immunité.

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