C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2135277
There is disclosed anti-receptor agents to the vitamin B12/transcobalamin II receptor. The anti-receptor agents antagonize or modulate the vitamin B12/transcobalamin II receptor, causing cellular depletion of vitamin B12, thus preventing or inhibiting cell division. Anti-receptor agents of the present invention include proteins (such as antibodies and antibody derivatives), peptides and small organic molecules. In a preferred embodiment, the anti- receptor agent is an antibody to the vitamin B12/transcobalamin II receptor.
L'invention concerne des agents antirécepteurs dirigés contre le récepteur de la vitamine B12/transcobalamine II. Lesdits agents antirécepteurs s'opposent à ou modulent le récepteur de la vitamine B12/transcobalamine II en provoquant la déplétion cellulaire de la vitamine B12, empêchant ou stoppant ainsi la division cellulaire. Les agents antirécepteurs selon l'invention comprennent des protéines (anticorps ou dérivés d'anticorps), des peptides et des petites molécules organiques. Dans un mode préféré de réalisation, l'agent antirécepteur est un anticorps dirigé contre le récepteur de la vitamine B12/transcobalamine II.
Gowling Lafleur Henderson Llp
Kyto Biopharma Inc.
Vitamed Inc.
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