Anti-receptor and growth blocking agents to the vitamin...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2199940

There is disclosed anti-receptor and growth blocking agents to the vitamin B 12/transcobalamin II receptor and binding sites. The anti-receptor and growth blocking agents antagonize or modulate the vitamin B12/transcobalamin II receptor or binding sites, causing cellular depletion of vitamin B12, thus inhibiting cell division or causing apoptosis. Anti-receptor and growth blocking agents of the present invention include proteins (such as antibodies and antibody derivatives), peptides and small organic molecules.

Agents antirécepteurs et inhibiteurs de croissance dirigés contre les sites de liaison et le récepteur de vitamine B¿12?/transcobalamine II. Ces agents antirécepteurs et inhibiteurs de croissance sont antagonistes ou modulateurs des sites de liaison ou du récepteur de vitamine B¿12?/transcobalamine II, et provoquent ainsi la déplétion cellulaire de la vitamine B¿12?, ce qui inhibe la division cellulaire ou entraîne l'apoptose. Ces agents antirécepteurs et inhibiteurs de croissance comprennent des protéines (telles que des anticorps et dérivés anticorpaux), des peptides et de petites molécules organiques.

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