C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/34 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2406033
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fc.gamma. receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby or for uses such as idiopathic thrombocytopenic purpura (ITP).
La présente invention concerne un procédé d'obtention et de sélection d'anticorps monoclonaux par un test de type ADCC, lesdits anticorps pouvant activer les récepteurs Fc.gamma. de type III et présentant une structure glycannique particulière. Les anticorps anti-D selon l'invention peuvent être utilisés pour la prévention de l'isoimmunisation Rhésus d'individus Rh négatifs, notamment de la maladie hémolytique du nouveau-né (MHNN) ou dans des applications comme le Purpura Thrombocytopénique Idiopathique (PTI).
Beliard Roland
Bihoreau Nicolas
Bourel Dominique
de Romeuf Christophe
Glacet Arnaud
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
Lfb Biotechnologies
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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