Anti-sclerostin antibodies

Details Anti-sclerostin antibodies Anti-sclerostin antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 19/10 (2006.01) C07K 16/22 (2006.01) C07K 14/51 (2006.01)

Patent

CA 2682212

Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.

L'invention concerne des anticorps humanisés et chimériques qui se lient spécifiquement à la sclérostine humaine et sont caractérisés en ce qu'ils présentent une affinité élevée et d'importantes propriétés de neutralisation. Les anticorps de l'invention sont utilisés pour augmenter la masse osseuse, la densité minérale osseuse et la résistance osseuse et pour traiter des troubles variés, par exemple, l'ostéoporose, chez un sujet humain.

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