Anti-sense nucleic acid derivative

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/04 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2096658

ABSTRACT OF THE DISCLOSURE A compound represented by general formula (1), its salt, and antiviral and antitumor drugs containing the same, wherein k is 0 to 20; m is 0 or 1; n is 4 to 29, X represents OH, methyl, sulfhydryl, C1 to C4 alkoxy or C1 to C6 monoalkylamino; Y and Z represent each O or S: R1, R2 and R3 may be the same or different from each other and each represents H, C1 to C6; alkyl, or C6 to C10 aryl which may have the substituent(s) of group .alpha.; and D and B represent each independently a residue of any of the compounds of group .beta.; provided that m is 0 when k is 0, and a base sequence containing B is complementary to a tumor gene or a virus gene: group .alpha.: OH, C1 to C6; alkyl, C1 to C6 alkoxy, methylenedioxy, nitro, azido, halogen, C6 to C10 aryl, C6 to C10 aryloxy, and aralkyloxy composed of a C6 to C10 aryl moiety and a C1 to C2 alkyl moiety, group .beta.: adenine, guanine, cytosine and thymine.

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