Anti-sense oligonucleotide sequence, anti-rna messenger of...

C - Chemistry – Metallurgy – 07 – H

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167/202, 195/1.1

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/525 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2023899

La demande concerne une séquence d'oligonucléotides anti- sens, anti-ARN messager du TNF alpha, de formule (I) : TCA TGG TGT CCT TTG CAG - X (I) dans laquelle X représente un hydrogène ou une séquence de 1 à 17 oligonucléotides sous forme libre, alcoylée, sulfurée ou de dérivés de la poly L-lysine, procédé de préparation, applica- tion à titre de médicament et compositions pharmaceutiques renfermant cette nouvelle séquence.

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