Anti-t cell and autoantigen treatment of autoimmune disease

Details Anti-t cell and autoantigen treatment of autoimmune disease Anti-t cell and autoantigen treatment of autoimmune disease

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 38/13 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 3/10 (2006.01) C12N 15/24 (2006.01) C12N 15/60 (2006.01)

Patent

CA 2596332

The invention is directed to a new method for the treatment of new onset Type I diabetes in mammals or for the treatment of pre-Type I diabetic mammals where the method comprises administering (a) anti-T cell therapy to the mammal and administering (b) an autoantigen and optional mucosal antigen composition, wherein (a) and (b) are administered concurrently or sequentially Exemplified is a treatment using a mixture of anti-CD3 antibodies, a glutamic acid decarboxylase (GAD) autoantigen, and an immunoregulatory cytokine Canme GAD sequences are also disclosed.

L'invention concerne un nouveau procédé pour le traitement d'un diabète de type I nouvellement apparu chez des mammifères ou pour le traitement de mammifères atteints de prédiabète de type I, lequel procédé comprend l'administration au mammifère (a) d'un traitement contre les lymphocytes T et l'administration (b) d'un antigène et en option d'une composition antigénique mucosale, (a) et (b) étant administrés en même temps ou l'un après l'autre. Un traitement utilisant un mélange d'anticorps anti-CD3 est donné en exemple, et un autoantigène de l'acide glutamique décarboxylase (GAD) et une séquence GAD canine de cytokine immunorégulatrice sont également présentées.

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