Anti-tcf-ii monoclonal antibodies and method for the...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/08 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) G01N 33/577 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2071622

ABSTRACT OF THE DISCLOSURE Disclosed are monoclonal antibodies having specific affinity to an anti-tumor protein, TCF-II, derived from human fibroblasts. The monoclonal antibodies have a molecular weight of approximately 150,000 and belong to a subclass of IgG1, with N-terminal amino acid sequence of the L chain identified. The monoclonal antibodies can be used for the purification of TCF-II and for the diagnosis of liver disease by measuring the content of TCF-II in the plasma by the aid of the monoclonal antibodies. 34

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