Anti-thrombotic peptides and pseudopeptides

Details Anti-thrombotic peptides and pseudopeptides Anti-thrombotic peptides and pseudopeptides

C - Chemistry, Metallurgy

07

K

C07K 5/04 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2069754

2069754 9107976 PCTABS00005 Disclosed are novel peptides and pseudopeptides and pharmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood of structure (I), wherein: X is H, amidino or (a); Y is H, amino or (b); Z is (c), OR1 or a naturally occuring L-amino acid, bounded to the carbon atom at the .alpha.-amino position; R is alkyl, aryl or aralkyl; R1 and R2 are independently H, alkyl, aryl, aralkyl or allyl; m is 1 through 5; n is 0 through 4; and pharmaceutically acceptable salts thereof.

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