C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) C07H 21/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2486930
A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises particular therapeutic and preventive treatment regimens for the administration of a T- cell immune response cDNA 7 (TIRC7) antagonist, preferably an anti-TIRC7 antibody. Particularly useful monoclonal, in particular chimeric anti-TIRC7 antibodies are described. Furthermore, a combination therapy for the treatment of an inflammatory disease, particularly rheumatoid arthritis, is provided involving the use of TIRC7 antagonist, such as anti-TIRC7 antibody in conjunction with an anti-inflammatory drug such as TNF-.alpha. antagonist
Cette invention porte sur une méthode de traitement de troubles inflammatoires et en particulier de l'arthrite. Cette méthode comprend des régimes de traitement préventifs et thérapeutiques particuliers pour l'administration d'un antagoniste de l'ADNc 7 à réponse immunitaire spécifique aux lymphocytes T (TIRC7), de préférence d'un anticorps anti-TIRC7. Cette invention concerne également des anticorps anti-TIRC7 monoclonaux, en particulier chimériques, particulièrement utiles. En outre, cette invention concerne une polythérapie servant au traitement d'une maladie inflammatoire, en particulier de la polyarthrite rhumatoïde, et faisant appel à un antagoniste du TIRC7, tel qu'un anticorps anti-TIRC7, utilisé conjointement à un anti-inflammatoire tel qu'un antagoniste du facteur TNF-.alpha..
Genpat77 Pharmacogenetics Ag
Sim & Mcburney
LandOfFree
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