C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) A61P 31/00 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2402596
The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding to an epitope in the C-terminal macromolecular substrate binding region of TF.
L'invention concerne des anticorps de facteur anti-tissulaire (anti-TF) à pouvoir anticoagulant amélioré, ainsi que des procédés et des moyens d'identification, de production et d'utilisation de tels anticorps. Ces anticorps anti-TF sont conçus afin de contenir une région de liaison à un épitope situé dans la région de liaison de substrat macromoléculaire C-terminale de TF.
Kirchhofer Daniel K.
Lowe David G.
Presta Leonard G.
Genentech Inc.
Smart & Biggar
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