C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2713786
An anti-TrkA antibody is provided that comprises: a) a variable heavy chain comprising a sequence selected fromany of BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5, or HuVHWOv as shown in Figure (1a); or from variants of any of said sequences and/or b) a variable light chain comprising a sequence selected from any of BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 or BXhVL8; as shown in Figure (1b), or from variants of any of said sequences.TrkA-binding derivatives are also provided. Antibodies or derivatives of the present invention are useful in a number of therapies, including pain therapy.
L'invention porte sur un anticorps anti-TrkA qui comprend : a) une chaîne lourde variable comprenant une séquence choisie parmi l'un quelconque de BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5 ou HuVHWOv tel que présenté sur la Figure (1a), ou provenant de variantes de l'une quelconque desdites séquences; et/ou b) une chaîne légère variable comprenant une séquence choisie parmi l'un quelconque de BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 ou BXhVL8, comme représenté sur la Figure (1b), ou provenant de variantes de l'une quelconque desdites séquences. L'invention porte également sur des dérivés de liaison à TrkA. Les anticorps ou dérivés de la présente invention sont utiles dans divers traitements, dont le traitement de la douleur.
Benigni Fabio
D'ambrosio Daniele
Goudreau Gage Dubuc
Lay Line Genomics S.p.a.
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