Anti-trop-2 monoclonal antibodies and uses thereof in the...

Details Anti-trop-2 monoclonal antibodies and uses thereof in the... Anti-trop-2 monoclonal antibodies and uses thereof in the...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2750038

The present invention teaches anti-Trop-2 monoclonal antibodies with high affinity and able to recognize different regions of the Trop-2 molecule, and uses thereof in the treatment and diagnosis of tumors, such as for example endometrium, breast, head and neck, colon-rectum, stomach, lung, ovary, prostate, pancreas, kidney, cervix and bladder (urothelial) tumors.

La présente invention porte sur des anticorps monoclonaux anti-Trop-2 à forte affinité et capables de reconnaître différentes régions de la molécule Trop-2, et sur leurs utilisations dans le traitement et le diagnostic de tumeurs, telles que par exemple des tumeurs de l'endomètre, du sein, de la tête et du cou, du côlon-rectum, de l'estomac, du poumon, des ovaires, de la prostate, du pancréas, du rein, du col de l'utérus, de la vessie (urothéliales).

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