Anti-tubulin acting arylpyrrol, arylfulran and arylthiopene...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 207/333 (2006.01) A61K 31/4015 (2006.01) C07D 207/32 (2006.01) C07D 207/335 (2006.01)

Patent

CA 2566038

The invention relates to a compound represented by general formula (I) wherein Z represents N, O or S, and a represents a CH group, a nitrogen atom or an NL?+¿ group wherein L represents a straight-chained or branched C¿1?-C¿12? alkyl group. The invention also relates to a method for the preparation thereof and the use thereof as an antimitotic.

La présente invention concerne un composé représenté par la formule générale (I) suivante dans laquelle : Z représente N, O ou S, et A représente un groupe CH, un atome d'azote ou un groupe NL+ dans lequel L représente un groupe alkyle en C1-C12 linéaire ou ramifié. Elle concerne en outre son procédé de préparation et son utilisation en tant qu'antimitotique.

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