C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/06 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2454345
The invention discloses anti-tumor activity in the sera of certain reptiles, more particularly in the serum of alligators or crocodiles. The active principle resides in one or more serum proteins or polypeptides that inhibit the growth of mammalian tumor cells in culture while being practically devoid of such inhibitory activity towards normal cells in culture. The active fractions obtained from the sera show no overt toxicity in healthy mammals, and this novel anti-tumor agent may therefore be used for the prevention, investigation, treatment or diagnosis of neoplasms.
L'invention concerne l'activité antitumorale manifestée dans le sérum de certains reptiles et notamment dans le sérum des alligators ou crocodiles. Le principe actif réside dans une ou plusieurs protéines ou un ou plusieurs polypeptides du sérum qui inhibent la croissance des cellules tumorales chez les mammaliens dans une culture tout en restant pratiquement exempts de cette activité d'inhibition par rapport aux cellules normales dans la culture. Les fractions actives obtenues à partir de ces sérums n'ont aucune toxicité manifeste chez les mammifères sains, et ce nouvel agent antitumoral peut ainsi être utilisé dans la prévention, la recherche, le traitement ou le diagnostic des néoplasmes.
Binah Ofer
Ciechanover Aaron
Maor Gila
Natural Cure Ltd.
Ridout & Maybee Llp
LandOfFree
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