Anti-tumor compositions containing 5, 5-dimethyl-2-...

Details Anti-tumor compositions containing 5, 5-dimethyl-2-... Anti-tumor compositions containing 5, 5-dimethyl-2-...

A - Human Necessities

61

K

167/234

A61K 31/425 (2006.01) C07D 277/06 (2006.01)

Patent

CA 1303505

ABSTRACT OF THE DISCLOSURE A composition for therapy of tumors having high tyrosinase activity contains the reaction product of penicil- lamine with a cytotoxic aldehyde, or pharmaceutically accep- table salts or esters thereof, and a pharmaceutically accep- table vehicle. The preferred compounds are 5,5-dimethyl-2- phenyl-4-thiazolidine carboxylic acid, or 5,5-dimethyl-2-(2- hydroxyphenyl)-4-thiazolidine carboxylic acid, or pharmaceuti- cally acceptable salts or esters thereof. Treatment prefer- ably comprises an intra-arterial drip. Diagnosis of tumors suitable for treatment by means of these compositions may be accomplished by administering a racioactive copper salt and scanning for accumulations of radioactivity. This will in?i- cate sites of high tyrosinase activity.

498057

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