C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 305/14 (2006.01) A61K 31/33 (2006.01) A61K 31/695 (2006.01) C07D 205/08 (2006.01) C07D 405/00 (2006.01) C07D 407/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2158147
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) with .beta.-lactams of formula (V). The invention also provides pharmaceutical compositions including the novel taxanes and methods for treatment of certain cancers with these new compounds.
La présente invention concerne de nouveaux taxanes utiles en tant qu'agents chimiothérapiques ou leurs précurseurs. Les procédés de préparation des nouveaux taxanes comportent la réaction couplée, en présence d'une base, de baccatine de formule (III) ou (IV) avec des beta-lactames de formule (V). L'invention propose également des compositions pharmaceutiques qui comprennent les nouveaux taxanes ainsi que des thérapeutiques anticancéreuses qui utilisent ces nouveaux composés.
Bombardelli Ezio
Ojima Iwao
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Indena S.p.a.
The Research Foundation Of State University Of New York Technology Transfer Office
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