C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/240, 167/242
C07D 209/30 (2006.01) A61K 31/33 (2006.01) C07D 209/08 (2006.01) C07D 333/50 (2006.01) C07D 333/54 (2006.01) C07D 333/72 (2006.01)
Patent
CA 1331464
Abstract of the Disclosure This invention provides anti-cancer compounds of the formula Image I wherein A is -S(O)n-, -CH2S(O)n-, -N(ethyl)-, or -CH2-; D is -CH2-, -S(O)n-, -NR-, or -CH2S(O)n-; B is -CH2-, -O-, -S(O)n-, or -NR-; R is methyl or ethyl; R1 is hydrogen or halo; R2 is halo or trifluoromethyl; n is 0-2; provided that: B is a group other than -CH2- only when A and D are both -CH2-; D is -CH2S(O)n- only when A is -S(O)n-, -N(ethyl)- or -CH2-; and no more than two of A, B and D are -CH2-; provided that neither A nor D can be -S(O)- unless either B or the other of A and D is a group other than -CH2-.
566099
Harper Richard Waltz
Howbert James Jeffry
Poore Gerald Auston
Rieder Brent Jeffrey
Tao Eddie Vi-Ping
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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