Anti-tumor method and compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 209/30 (2006.01) A61K 31/33 (2006.01) C07D 209/08 (2006.01) C07D 333/50 (2006.01) C07D 333/54 (2006.01) C07D 333/72 (2006.01)

Patent

CA 1331464

Abstract of the Disclosure This invention provides anti-cancer compounds of the formula Image I wherein A is -S(O)n-, -CH2S(O)n-, -N(ethyl)-, or -CH2-; D is -CH2-, -S(O)n-, -NR-, or -CH2S(O)n-; B is -CH2-, -O-, -S(O)n-, or -NR-; R is methyl or ethyl; R1 is hydrogen or halo; R2 is halo or trifluoromethyl; n is 0-2; provided that: B is a group other than -CH2- only when A and D are both -CH2-; D is -CH2S(O)n- only when A is -S(O)n-, -N(ethyl)- or -CH2-; and no more than two of A, B and D are -CH2-; provided that neither A nor D can be -S(O)- unless either B or the other of A and D is a group other than -CH2-.

566099

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