C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/16 (2006.01) A61K 39/00 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2725526
The present invention relates to the field of preventive or therapeutic anti- tumoral vaccine. More specifically, the present invention relates to live animal tumour cells having a negative MHC-I phenotype, to methods for the production of such MHC-I negative cells, and to their therapeutic use as anti-tumoral agents, particularly via their capacity to activate natural killer (NK) cells. The invention further relates to methods for modulating the level of expression of MHC-I molecules on animal tumour cells, for example by use of specific culture conditions, and / or by use of exogenous agents which directly or indirectly affect lev-els of MHC-I expression. The invention also concerns activated NK cells and their therapeutic use as anti-tumoral agents.
La présente invention concerne le domaine des vaccins anti-tumoraux préventifs ou thérapeutiques. Plus spécifiquement, la présente invention concerne des cellules tumorales animales vivantes ayant un phénotype MHC-I négatif, des procédés de production de telles cellules à MHC-I négatif, et leur utilisation thérapeutique en tant quagents anti-tumoraux, notamment par le biais de leur capacité à activer les cellules tueuses naturelles (NK). Linvention concerne également des procédés de modulation du niveau dexpression de molécules MHC-I sur des cellules tumorales animales, par exemple en utilisant des conditions de culture spécifiques et/ou en utilisant des agents exogènes qui affectent directement ou indirectement les niveaux dexpression de MHC-I. Linvention concerne également des cellules NK activées et leur utilisation thérapeutique en tant quagents anti-tumoraux.
Cherni Seyma
de Bettignies Geoffroy
Garaude Johan
Hipskind Robert
Jacquet Chantal
Centre National de La Recherche Scientifique
Robic
Universite de Montpellier 1
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