Anti-tumoral compositions and methods

Details Anti-tumoral compositions and methods Anti-tumoral compositions and methods

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2614608

Described are methods and compositions for inhibiting undesired cells by expression of one or more exogenous enzymes in the cells and administration of a prodrug which is a substrate for at least one of the enzymes to produce a cytotoxic compound. Inventive methods and compositions are active to inhibit cells expressing the exogenous enzymes as well as bystander cells. Tumor cells are a particular target for inhibition using methods and compositions detailed according to the present invention. Provided are methods and compositions for improved anti-tumoral effects by overexpression of adenine phosphoribosyltransferase (APRT) to produce cytotoxins which inhibit the cells overexpressing the APRT as well as bystander cells. Overexpression of APRT in conjunction with expression of E. coli PNP and administration of a substrate for E. coli PNP provides particularly effective anti-tumoral effects.

L'invention concerne des méthodes et des compositions servant à inhiber des cellules indésirables par expression d'un ou de plusieurs enzymes exogènes dans ces cellules et administration d'un promédicament constituant un substrat pour au moins un de ces enzymes afin de produire un composé cytotoxique. Ces méthodes et ces compositions permettent d'inhiber activement des cellules exprimant les enzymes exogènes ainsi que des cellules bystander. Les cellules tumorales constituent une cible particulière d'inhibition au moyen de ces méthodes et de ces compositions. Elle concerne également des méthodes et des compositions servant à améliorer les effets antitumoraux par surexpression d'adénine phosphoribosyltransférase (APRT) afin de produire des cytotoxines inhibant les cellules surexprimant APRT, ainsi que les cellules bystander. La surexpression d'APRT en combinaison avec l'expression de E.coli PNP et l'administration d'un substrat pour E.coli PNP permet d'obtenir des effets antitumoraux particulièrement efficaces.

Affiliated with

Also associated with

Rating

Anti-tumoral compositions and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-tumoral compositions and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-tumoral compositions and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1954289