Anti-tumour agents

Details Anti-tumour agents Anti-tumour agents

C - Chemistry, Metallurgy

07

D

167/208, 260/254

C07D 239/72 (2006.01) C07D 239/90 (2006.01) C07D 239/95 (2006.01) C07D 239/96 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2005476

A B S T R A C T TITLE: ANTI-TUMOUR AGENTS The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- Image I wherein R1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R1 is substituted alkyl or alkoxy each of up to 3 carbon atoms; R2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula -CO.NH-, -NH.CO-, -CO.NR3-, -NR3.CO-, -CH=CH-, -CH2O-, -OCH2-, -CH2S-, -SCH2-, -CO.CH2-, -CH2.CO- or -CO.O-, wherein R3 is alkyl of up to 6 carbon atoms; and Y is aryl or heteroaryl or a hydrogenated derivative thereof; or Y is a group of the formula -A-Y1 in which A is alkylene, cycloalkylene, alkenylene or alkynylene each of up to 6 carbon atoms and Y1 is aryl or heteroaryl or a hydrogenated derivative thereof; or a pharmaceutically-acceptable salt thereof.

Affiliated with

Also associated with

Rating

Anti-tumour agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-tumour agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-tumour agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1348728