Anti-tumour agents

Details Anti-tumour agents Anti-tumour agents

C - Chemistry, Metallurgy

07

C

C07C 219/34 (2006.01) A61K 31/215 (2006.01) C07D 295/12 (2006.01) C07D 295/135 (2006.01)

Patent

CA 2324361

The invention concerns anti-tumour agents of formula (I) wherein each of R1, R2 and R3 has the meanings defined in the specification including hydrogen, (1- 4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, amino, (1-4C)alkylamino and (1- 4C)alkoxy; each of R4 and R5 is (1-4C)alkyl; each of R6 and R7 is hydrogen or (1-4C)alkyl; X is oxygen; m is 1 or 2 and each R8 is as defined in the specification; each of Y1 and Y2 is halogeno, (1-4C)alkanesulphonyloxy, benzenesulphonyloxy or phenyl-(1-4C)alkanesulphonyloxy; or a pharmaceutically- acceptable salt thereof; provided that at least one of R1, R2 and R3 is other than hydrogen; a process for their preparation, pharmaceutical compositions containing them and their use in the production of an anti-proliferative effect.

La présente invention concerne des agents antitumoraux de formule (I) où chacun des groupes R?1¿, R?2¿ et R?3¿ répond aux définitions données dans les spécifications, dont hydrogène, (1-4C) alkyle, (3-4C) alkényle, (3-4C) alkynyle, amino, (1-4C) alkylamino et (1.4C) alkoxy; chacun des groupes R?4¿ et R?5¿ est (1-4C) alkyle; chacun des groupes R?6¿ et R?7¿ est hydrogène ou (1-4C) alkyle; X est oxygène; m correspond à 1 ou 2 et chaque groupe R?8¿ est conforme aux spécifications; chacun des groupes Y?1¿ et Y?2¿ est halogéno, (1-4C)alkanesulphonyloxy, benzènesulphonyloxy ou phényle- (1-4C) alkanesulphonyloxy; ou bien un sel pharmaceutiquement acceptable de ces composés; à condition qu'au moins un des groupes R?1¿, R?2¿ et R?3¿ soit autre qu'hydrogène. Cette invention concerne également un procédé relatif à la préparation de ces agents, des compositions pharmaceutiques renfermant ces agents et leur utilisation à des fins antiprolifératives.

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