Anti-tumour compounds

Details Anti-tumour compounds Anti-tumour compounds

C - Chemistry, Metallurgy

07

D

C07D 239/88 (2006.01) A61K 31/505 (2006.01) C07D 239/90 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2042922

ABSTRACT TITLE: ANTI-TUMOUR COMPOUNDS The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- Image I wherein R1 includes hydrogen, amino and alkyl or alkoxy each of up to 4 carbon atoms; R2 includes hydrogen, alkyl, hydroxyalkyl and halogenoalkyl each of up to 4 carbon atoms; R3 is hydrogen or alkyl or up to 3 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula -CO.NH-, -NH.CO-, -CO.NR4-, -NR4.CO-, -CH=CH- or -CO.O-, wherein R4 is alkyl of up to 4 carbon atoms; and Y is a branched alkyl group bearing substituents Y2 and Y3 the definition of each independently including hydroxy, cyano, aryl and heteroaryl, and the definition of Y3 also optionally including sulpho, N-phenylsulphonylcarbamoyl and 5-tetrazolyl; or a pharmaceutically-acceptable salt thereof.

Affiliated with

Also associated with

Rating

Anti-tumour compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-tumour compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-tumour compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1365346