Anti-tyrp1 antibodies

Details Anti-tyrp1 antibodies Anti-tyrp1 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2718289

The present invention provides for fully human antibodies and chimeric antibodies that bind human TYRP1 antigen with an affinity comparable to or higher than TA99, a murine antibody specific to TYRP1. The invention further provides polynucleic acids and host cells that encode and express these antibodies. The invention also provides for methods of modulating activity of TYRP1, treating growth of a cancer cell, and treating a malignant melanoma in mammals by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment.

La présente invention concerne des anticorps entièrement humains, ou des anticorps chimères, qui se lient à l'antigène humain TYRP1 avec une affinité supérieure ou égale au clone TA99, un anticorps murin spécifique à l'antigène TYRP1. Linvention concerne par ailleurs des acides polynucléiques et des cellules hôtes qui encodent et expriment ces anticorps. Et linvention concerne également des procédés pour moduler l'activité de l'antigène TYRP1, traiter la croissance d'une cellule cancéreuse, et traiter un mélanome malin chez des mammifères, en administrant une quantité efficace d'un anticorps, soit de manière isolée, soit en combinaison avec un agent ou un traitement anticancéreux.

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