Anti-ulceric sulfonamidines

Details Anti-ulceric sulfonamidines Anti-ulceric sulfonamidines

C - Chemistry, Metallurgy

07

D

167/207, 260/301

C07D 277/42 (2006.01) C07D 233/54 (2006.01) C07D 277/48 (2006.01) C07D 285/135 (2006.01) C07D 295/096 (2006.01) C07D 295/12 (2006.01) C07D 307/52 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1269382

ABSTRACT OF THE DISCLOSURE: The invention relates to new sulfonamidines of -the general formula (I): R - NH - CH = N - SO2 - R1 (I) wherein R is a group selected from 2-[[(5-methyl-1H- imidazole-4-yl)methyl]thio]ethyl, 2-[[[5-[(dimethylamino) methyl]-2-furanyl]methyl]thio]ethyl, 2-[[[2-C(aminoimino- methyl)amino]-4-thiazolyl]methyl thio ethyl or 3-[3-(1- piperidinylmethyl)phenoxy]propyl and R1 is alkyl; or a phenyl group optionally substituted by alkyl, halogen, nitro, alkoxy, alkanoylamino, carboxylic acid, alcoxycar- bonyl, dialkylamino, alkylsulphonyl, al]cylsulphonylamino or alkylthio; or 1,3,4-thiadiazole-2-yl substituted by alkanoylamino, and the pharmaceutically acceptable salts thereof, as well as to a process for preparing these compounds and to pharmaceutically compositions containing these compounds. These compounds have antiulcer activity and can be used in the treatment of peptic ulcers and other pathologies caused or stimulated by gastric acidity.

477755

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