Anti-urokinase monoclonal antibody, matrix bearing it, test...

Details Anti-urokinase monoclonal antibody, matrix bearing it, test... Anti-urokinase monoclonal antibody, matrix bearing it, test...

A - Human Necessities

61

K

195/33, 167/44,

A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/72 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) G01N 33/86 (2006.01)

Patent

CA 1297818

ABSTRACT The present invention relates to a class of new IgG1 monoclonal antibodies, directed to an epitope on human urokinase, which selectively bind to high molecular weight urokinase (54,000), or a single-chain precursor thereof, without binding to low molecular weight urokinase (33,000) have an affinity constant for urokinase which is suitable for use in an immuno- adsorption-based purification system and does not impair the enzymatic activity of urokinase. This antibody is also useful in immunoassays.

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