G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/74 (2006.01) A61K 31/498 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2549579
This invention is directed to potent inhibitors of protein tyrosine kinase alone or in synergistic combination with antiangiogenic or chemotherapeutic agents for the abrogation of mature vasculature within chemotherapeutic refractory tumors, pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cell proliferation, and particularly treatment of brain cancer, ovarian cancer, pancreatic cancer prostate cancer, and human leukemias, such as CML, AML or ALL.
L'invention concerne des inhibiteurs puissants de tyrosine kinase seuls ou en combinaison synergique avec des agents antiangiogènes ou chimiothérapiques afin d'éliminer la vascularisation mature dans des tumeurs réfractaires à la chimiothérapie, des compositions pharmaceutiques contenant ces composés, ainsi que l'utilisation de ces derniers pour traiter un patient souffrant de troubles/états induits par une prolifération cellulaire, ou sujet à ces troubles, et, plus particulièrement, pour le traitement du cancer du cerveau, des ovaires, du pancréas ou de la prostate, des leucémies humaines, telles que CML, AML ou ALL.
He Wei
Myers Michael R.
Nesbit Mark
Spada Alfred P.
Aventis Pharma S.a.
Aventis Pharmaceuticals Inc.
Centelion
Robic
LandOfFree
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