Anti-vegf antibodies

Details Anti-vegf antibodies Anti-vegf antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2533297

Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the synthetic antibodies in research, diagnostic and therapeutic applications.

L'invention concerne des anticorps anti-VEGF et leurs variantes, y compris ceux qui présentent une affinité élevée de fixation avec VEGF. Elle concerne également des méthodes de mise en application de techniques d'expression phagiques dans des banques naïves afin de générer et de sélectionner les anticorps anti-VEGF possédant l'activité de fixation souhaitée ou d'autres activités biologiques. Elle concerne, de plus, des utilisations de ces anticorps dans des domaines scientifiques, diagnostiques et thérapeutiques.

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