C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2705152
Disclosed are human antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two primary VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new human antibody- based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate compositions and methods using the new VEGF- specific human antibodies are also provided.
L'invention porte sur des anticorps humains qui inhibent spécifiquement une liaison de VEGF à un seul (VEGFR2) des deux récepteurs de VEGF primaires. Les anticorps inhibent efficacement l'angiogenèse et induisent la régression de tumeur et présentent cependant une sécurité améliorée en raison de leur spécificité. La présente invention propose ainsi de nouvelles compositions à base d'anticorps humains, des procédés et des protocoles combinés pour traiter le cancer et d'autres maladies angiogéniques. L'invention porte également sur des compositions avantageuses d'immunoconjugé et sur des procédés d'utilisation des nouveaux anticorps humains spécifiques de VEGF.
Kavlie Anita
Schlunegger Kyle
Affitech Research As
Peregrine Pharmaceuticals Inc.
Smart & Biggar
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