Anti-viral aromatic o-alkylated oximes, ethers and thioethers

Details Anti-viral aromatic o-alkylated oximes, ethers and thioethers Anti-viral aromatic o-alkylated oximes, ethers and thioethers

C - Chemistry, Metallurgy

07

D

C07D 307/68 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) A61P 31/12 (2006.01) C07C 251/38 (2006.01) C07C 333/08 (2006.01) C07D 207/34 (2006.01) C07D 263/34 (2006.01) C07D 277/56 (2006.01) C07D 307/30 (2006.01) C07D 309/32 (2006.01) C07D 319/12 (2006.01) C07D 327/06 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2163175

Compounds of the formula (see formula I) wherein Q is (see formula II) or -XR' ; X is oxygen or sulphur; R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy; R2 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C3-C4 alkenyloxy, C3-C4 alkynyloxy, mono-, di- or tri- halomethyl, trifuluoromethoxy, C1-C4 alkylthio, C3-C4 branched alkylthio, nitro, or cyano; R3 is hydrogen or C1-C4 alkyl; R 4 is C3-C6 alkenyl, C3-C6 alkynyl, C1-C8 haloalkyl, C1-C8 alkoxyalkyl, C1-C8 alkylthioalkyl, C1-C8 hydroxyalkyl, C1-C8 acyloxyalkyl, C1-C8 aroyloxyalkyl, C1-C8 carboxyalkyl, C1-C8 alkylcarboxyalkyl, C6-C12 arylcarboxyalkyl, C1-C8 aminoalkyl, C1-C8 alkylaminoalkyl, C1-C8 dialkylaminoalkyl, C1-C8 trialkylsilylalkyl, wherein each of the aforementioned alkyl moieties may be straight-chain or branched; C3-C8 cycloalkyl, C1-C6 alkylphenyl, C7-C12 arylalkyl, C7-C12 alkarylalkyl, or heterocyclylalkyl, wherein the heterocyclic moiety is morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, oxiranyl, oxetanyl, furanyl, tetrahydropyranyl or tetrahydrofuranyl; R' is C1-C8 haloalkyl, C1-C8 alkoxyalkyl, C1-C8 alkylthioalkyl, C1-C8 hydroxyalkyl, C1-C8 acyloxyalkyl, C1-C8 aroyloxyalkyl, C1-C8 aminoalkyl, C1-C8 alkylaminoalkyl, C1-C8 dialkylaminoalkyl, C1-C8 trialkylsilylalkyl, wherein each of the aforementioned alkyl moieties may be straight-chain or branched; C1-C6 alkylphenyl, C7-C12 arylalkyl, C7-C12 alkarylalkyl, or heterocyclylalkyl, wherein the heterocyclic moiety is morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, oxiranyl, oxetanyl, furanyl, tetrahydropyranyl or tetrahydrofuranyl; R5 is hydrogen, halo, methyl, mono-, di- or tri-halomethyl; and R6 is an aliphatic or cyclic side chain as defined herein. These compounds are useful for inhibiting the growth or replication of retroviruses such as HIV.

Affiliated with

Also associated with

Rating

Anti-viral aromatic o-alkylated oximes, ethers and thioethers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-viral aromatic o-alkylated oximes, ethers and thioethers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-viral aromatic o-alkylated oximes, ethers and thioethers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1497744