A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) C07D 235/30 (2006.01)
Patent
CA 2293508
The present application provides a series of benzimidazole compounds of formula (I), which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such as polioviruses, coxsackieviruses of the A and B groups, or echo virus, cardioviruses such as encephalomyocarditis (EMC), apthoviruses such as foot and mouth disease virus, and flaviviruses such as hepatitis C virus and bovine viral diarrhea virus. Such compounds are also useful as intermediates for preparing additional benzimidazole antiviral compounds.
L'invention concerne une série de composés à base de benzimidazole, représentés par la formule (I), qui inhibent la croissance de picornavirus, comme les rhinovirus (bovin et humain), d'entérovirus, comme les poliovirus, des virus Coxsackie A et B, ou des échovirus, de Cardiovirus comme le virus encéphalomyocardique, d'aphtovirus comme le virus de la fièvre aphteuse, et de flavivirus comme le virus de l'hépatite C et le virus de la diarrhée virale des bovins. Les composés considérés conviennent également comme produits intermédiaires dans l'élaboration de composés antiviraux additionnels à base de benzimidazole.
Dunlap Steven Eugene
Jungheim Louis Nickolaus
Tebbe Mark Joseph
Voy Gilbert Thomas
Werner John Arnold
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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