Anti-viral compounds

Details Anti-viral compounds Anti-viral compounds

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/18 (2006.01) A61K 31/52 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1287832

16672IA ANTI-VIRAL COMPOUNDS THIS IS A DIVISIONAL APPLICATION OF APPLICATION SERIAL NUMBER 410,092, FILED AUGUST 25, 1982 ABSTRACT OF DISCLOSURE 9-(1,3-dihydroxy-2-propoxymethyl)guanine and 9-(2,3-dihydroxy-1-propoxymethyl)guanine have been found to have potene anti-viral activity against herpes viruses. These compounds, their acyl dervatives, their phosphate derivatives and their pharmaceutically acceptable salts, pharmaceutical formulations containing these compounds, the treatment of viral infections with these compounds, methods of preparing these compounds, and novel intermediates useful in their preparation are all disclosed. The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetylquanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.

615600

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