Anti-viral compounds

Details Anti-viral compounds Anti-viral compounds

C - Chemistry, Metallurgy

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C07D 473/18 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) C07D 473/00 (2006.01) C07F 9/547 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1300622

16672Y ANTI-VIRAL COMPOUNDS ABSTRACT OF DISCLOSURE 9-(1,3-dihydroxy-2-propoxymethyl)guanine and 9-(2,3-dihydroxy-1-propoxymethyl)guanine have been found to have potent anti-viral activity against herpes viruses. These compounds, their acyl derivatives, their phosphate derivatives and their pharmaceutically acceptable salts, pharmaceutical formulations containing these compounds, the treatment of viral infections with these compounds, methods of preparing these compounds, and novel intermediates useful in their preparation are all disclosed. The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetylguanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.

410092

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