C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/220, 260/242
C07D 473/18 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) C07D 473/00 (2006.01) C07F 9/547 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 1300622
16672Y ANTI-VIRAL COMPOUNDS ABSTRACT OF DISCLOSURE 9-(1,3-dihydroxy-2-propoxymethyl)guanine and 9-(2,3-dihydroxy-1-propoxymethyl)guanine have been found to have potent anti-viral activity against herpes viruses. These compounds, their acyl derivatives, their phosphate derivatives and their pharmaceutically acceptable salts, pharmaceutical formulations containing these compounds, the treatment of viral infections with these compounds, methods of preparing these compounds, and novel intermediates useful in their preparation are all disclosed. The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetylguanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.
410092
Ashton Wallace T.
Field Arthur K.
Karkas John D.
Tolman Richard L.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
LandOfFree
Anti-viral compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-viral compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-viral compounds will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1316647