A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2332403
The present invention relates to compounds of Formula (I), which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. In said Formula, A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N-OH, O, or CHR1; R1 is hydrogen, halo, CN, C1-C4 alkyl, -CCH, CO(C1-C4 alkyl), CO2(C1-C4 alkyl), or CONR2R3; R2 and R3 are independently hydrogen or C1-C4 alkyl; A' is hydrogen, halo, C1-C6 alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of formula (II); R4 is C1-C6 alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5 is independently at each occurance hydrogen or halo; m is 1, 2, 3, or 4; and R6 is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4 alkyl, or CO2(C1-C4 alkyl), C1-C4 alkoxy; or pharmaceutically acceptable salts thereof.
L'invention concerne des composés de formule (I), qui inhibent la prolifération des picornavirus, des virus de l'hépatite, des entérovirus, des cardiovirus, des poliovirus, des virus Coxsackie des types A et B, de l'échovirus et du Mengovirus. Dans ladite formule (I), A représente phényle, pyridyle, phényle substitué, pyridyle substitué, ou benzyle; R représente hydrogène, COR?4¿, ou COCF¿3?; X représente N-OH, O ou CHR?1¿; R?1¿ représente hydrogène, halo, CN, alkyle C¿1?-C¿4?, -C?CH, CO(alkyleC¿1?-C¿4?), CO¿2?(alkyleC¿1?-C¿4?), ou CONR?2¿R?3¿; R?2¿ et R?3¿ représentent indépendamment hydrogène ou alkyle C¿1?-C¿4?; A' représente hydrogène, halo, alkyle C¿1?-C¿6?, benzyle, naphtyle, thiényle, furyle, pyridyle, pyrollyle, COR?4¿, S(O)¿n?R?4¿ ou un groupe de formule (II); R?4¿ représente alkyle C¿1?-C¿6?, phényle, ou phényle substitué; n vaut 0, 1 ou 2; R?5¿ représente séparément à chaque apparition hydrogène ou halo; m vaut 1, 2, 3 ou 4; et R?6¿ représente hydrogène, halo, CF¿3?, OH, CO¿2?H, NH¿2?, NO¿2?, CONHOCH¿3?, alkyle C¿1?-C¿4?, ou CO¿2?(alkyleC¿1?-C¿4?), alcoxy C¿1?-C¿4?; ou des sels desdits composés, acceptables au plan pharmaceutiques.
Ezquerra-Carrera Jesus
Gruber Joseph Michael
Hamdouchi Chafiq Hamdouchi
Holmes Richard Elmer
Spitzer Wayne Alfred
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Anti-viral compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-viral compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-viral compounds will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1592477