C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/70 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/55 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/052 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2748719
The compounds provided herein are suitable for inhibiting a virus in a patient and for treating a patient suffering from a viral infection such as an influenza virus. Also provided is a method for screening of compounds for use in treating and preventing viral infections. The assay screens compounds for activity against an influenza virus by measuring the cytopathogenic effect (CPE) of the compound on influenza infected-cells using precent cell viability as the end point.
L'invention porte sur des composés appropriés à inhiber un virus chez un patient et à traiter un patient souffrant d'une infection virale telle qu'un virus de la grippe. L'invention porte également sur un procédé de criblage de composés destinés à être utilisés pour le traitement et la prévention des infections virales. Le dosage crible des composés pour déterminer une activité contre un virus de la grippe par mesure de l'effet cytopathogène (CPE) du composé sur les cellules infectées par la grippe à l'aide d'une viabilité cellulaire en pourcentage en tant que critère d'évaluation.
Chen Xi
Jonsson Colleen B.
Maddry Joseph A.
Noah Diana L.
Noah James W.
Ridout & Maybee Llp
Southern Research Institute
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