C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/04 (2006.01) A61K 31/155 (2006.01) A61K 31/38 (2006.01) A61K 31/445 (2006.01) A61K 31/70 (2006.01) C07C 279/08 (2006.01) C07D 211/34 (2006.01) C07D 335/02 (2006.01)
Patent
CA 2176760
Novel guanidino-substituted compounds are described having general formula (I) or a salt, hydrate or solvate thereof, wherein X is selected from C, O, N and S; R1 is -(W)a-(R4)b-Z, wherein a and b are independently 0 or 1; W is NH, O or S; R4 is C1-8alkylene in which one or two of the carbon atoms thereof is optionally replaced with nitrogen or oxygen; and Z is H, OH or -NH-C(NH)-NH2; R2 and R3 are, independently, C1-8alkylene in which one of the carbon atoms thereof is optionally replaced with nitrogen or oxygen. These compounds have been found to inhibit effectively herpesvirus replication. Particularly preferred compounds in accordance with formula (I) for this purpose are guanidino-substituted sugar derivatives.
L'invention concerne des nouveaux composés à substitution guanidino représentés par la formule générale (I), ou un sel, un hydrate ou un solvate de ces derniers, X étant choisi parmi C, O, N et S; R¿1? correspondant à -(W)¿a?-(R¿4?)¿b?-Z, a et b étant indépendamment 0 ou 1; W correspondant à NH, O ou S; R¿4? représentant alkylène C¿1-8? dont un ou plusieurs atomes de carbone sont éventuellement remplacés par azote ou oxygène; et Z représentant H, OH ou -NH-C(NH)-NH¿2?; R¿2? et R¿3? représentant indépendamment alkylène C¿1-8? dont un atome de carbone est éventuellement remplacé par azote ou oxygène. Ces composés s'avèrent être très efficaces pour inhiber la réplication de l'herpèsvirus. A cet effet, les composés particulièrement préférés selon la formule (I) sont des dérivés de sucre à substitution guanidino.
Rakhit Sumanas
Slassi Abdelmalik
Allelix Biopharmaceuticals Inc.
Ridout & Maybee Llp
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